罗晓明，女，1982年10月生，四川简阳人，汉族，中共党员，博士，硕士研究生导师，副教授，金沙2004线路检测预防医学教研室主任。邮箱：lxm@cmc.edu.cn

主要研究方向：药物控释及缓释制剂，环境有害物质及纳米材料毒性作用机制。主持国家自然科学基金、四川省教育厅等各级科研课题5项；授权专利1项；发表论文24篇（SCI 20篇）。

主要教育教学工作：承担《预防医学》、《卫生毒理学》2门本科生课程和《环境健康科学概论》1门研究生课程教学工作。其中，负责的《预防医学》获批四川省一流线下课程。参编“十二五”普通高等教育本科国家级规划教材、“十三五”全国高等医学院校本科规划教材1部。

一、教育及工作经历

1. 2001年9月 至2006年6月 成都医学院 临床医学 学士

2. 2008年9月 至2014年12月 西南交通大学 材料学 博士（硕博连读）

3. 2015年1月 至2017年11月 成都医学院预防医学教研室 讲师

4. 2017年11月至今 成都医学院预防医学教研室 副教授

二、研究成果

主持或参加科研项目（课题）及人才计划项目情况

1.四川养老与老年健康协同创新中心项目，YLZBZ2001，基于EcN细菌和Janus粒子构建“混合动力”马达用于乏氧肿瘤的药物递送，2021/01-2022/12，3万元，在研，主持

2.成都医学院科研基金，创新科研团队，CYTD19-02，自驱动电纺纤维微马达在肿瘤检测和治疗中的应用，2020/01-2021/12，5万元，在研，主持

3.国家自然科学基金，青年基金，51803015，适配体修饰自驱动微马达的构建及CTCs的精准检测，2119/01-2021/12，25万元，在研，参加

4.国家自然科学基金青年，81501581，EcN细菌修饰聚合物纳米粒子靶向肿瘤研究，2016/01-2018/12，21.52万元，结题，主持

5.四川省教育厅自然科学重点项目，15ZA0254，可注射性载生物活性大分子短纤维治疗骨性关节炎的研究，2015/01-2016/12，0.5万元，结题，主持

6.成都医学院校基金重点项目，14Z088，可注射性载CA4P/DOX的凝胶/短纤维复合药物控释系统抗肿瘤效果研究，2015/01-2016/12, 4万元，结题，主持

7.国家自然科学基金(81773432)：Delphinidin防护视网膜光化学损伤效应及分子机制研究，2018/01-2021/12，60+48万，在研，参加

三、发表论文情况

1.Zhaoqiong Chen #, Dan Zhao # , Mingliang Li, Weiguo Tu,xiaoming Luo**, Xin Liu *, A field study on the effects of combined biomanipulation on the water

quality of a eutrophic lake.Environmental Pollution.265 (2020) 115091.（JCR1区，IF：8.071）

2.Qin Han, Kejie Chen, Chunli Su, Xin Liu,Xiaoming Luo.Puerarin Loaded PLGA Nanoparticles: Optimization Processes of Preparation and Anti-alcohol Intoxication Effects in Mice.AAPS PHARMSCITECH.DOI10.1208/s12249-021-02092-w(IF:3.246)

3.XiaomingLuo #, HaixingSong #, JingY ang, BinHan, YeFeng, YanbingLeng **,ZhaoqiongChen*. Encapsulation of Escherichia coli strain Nissle 1917 in a chitosan―alginate matrix by combining layer-by-layer assembly with CaCl₂cross-linking for an effective treatment of inflammatory bowel diseases. Colloids and Surfaces B: Biointerfaces.2020, 189: 110818.（JCR1区，IF：5.268）

4.罗晓明#，毛皓月，杨铃，韩彬，苏春丽，宋海星*. EcN共价PSMA/PELA载药微球的制备及其靶向肿瘤低氧环境的初步研究.第三军医大学学报，2019, 41 (10) : 947-954.（北大中文核心）

5.Zhaoqiong Chen^＃, Xin Liu, Yingwei Ai, Jiao Chen,Xiaoming Luo*,Shu Yang,Zhen Kang, Shihong Zhong, Wei Li.How backfill soil type influencing on Cd and Pb migration in artificial soilon railway rock-cut slopes.Science of the TotalEnvironment2019,665:531–537.（2区，IF：6.551）

6.Zhaoqiong Chen＃, Xin Liu, Yingwei Ai, Jiao Chen,Xiaoming Luo*, Jing yao Chen, Shihong ZhongiEffects and mechanisms of revegetation modes on cadmium and leadpollution in artificial soil on railway rock-cut slopes.Science of the Total Environment, 2018,644:1602–1611.（2区，IF：6.551）

7.Xiaoming Luo,Maohua Chen, Zhoujiang Chen, Songzhi Xie, Nan He, Tao Wang, Xiaohong Li.An implantable depot capable of in situ generation of micelles to achievecontrolled and targeted tumor chemotherapy.Acta Biomaterialia,2018,67:122–133.( 1区，IF：7.242)

8.Chen, MH,Zhang, Y,Chen, ZJ,Xie, SZ,Luo, XM,Li, XH.Synergistic antitumor efficacy of redox and pH dually responsive micelleplexes for co-delivery of camptothecin and genes.ACTA BIOMATERIALIA.2017.49:444-455..( 1区，IF：7.242)

9.Xiaoming Luo,Maohua Chen, Yun Zhang, Zhoujiang Chen, Xiaohong Li*. Pharmacokinetics and antitumor efficacy of micelles assembled from multiarmed amphiphilic copolymers with drug conjugates in comparison with drug-encapsulated micelles, European Journal of Pharmaceutics and Biopharmaceutics, 2016, 98: 9–19( 2区，IF：4.604)

10.Zhang H, Liu Y, Chen MH, Luo XM, Li XH.Shape effects of electrospun fiber rods on the tissue distribution and antitumor efficacy.JOURNAL OF CONTROLLED RELEASE.2016, 244:52-62. .( 1区，IF：9.776)

11.Xiaoming Luo^＃, Guisen Xu＃, Jiaojun Wei, Maohua Chen, Hong Zhang, Xiaohong Li*, Tunable release of chemotherapeutic and vascular disrupting agents from injectable fiber fragments potentiates combination chemotherapy, International journal of pharmaceutics. 2016, 506: 1-12( 2区，IF：4.845)

12.Wei JJ,Luo XM, Chen MH, Lu JF,Li XH.Spatial distribution and antitumor activities after intratumoral injection of fragmented fibers with loaded hydroxycamptothecin.ACTA BIOMATERIALIA.2015,23:189-200.

13.Zhang Y,Chen MH, Luo XM, Zhang H,Liu CY,Li HY,Li XH.Tuning multiple arms for camptothecin and folate conjugations on star-shaped copolymers to enhance glutathione-mediated intracellular drug delivery.POLYMER CHEMISTRY.2015:6:2192-2203.

14.Xiaoming Luo^＃,Guoqing Jia＃, Haixing Song , Chaoyu Liu , Guannan Wu, Xiaohong Li*, Promoting Antitumor Activities of Hydroxycamptothecin by Encapsulation into Acid-Labile Nanoparticles Using Electrospraying. Pharmaceutical Research. 2014, 31: 46–59(2区，IF：3.242)

15.Liu CY, Yuan J,Luo XM, Chen MH, Chen ZJ, Zhao YC, Li XH.Folate-Decorated and Reduction-Sensitive Micelles Assembled from Amphiphilic Polymer-Camptothecin Conjugates for Intracellular Drug Delivery.MOLECULAR PHARMACEUTICS.2014,11:4258-4269.(1区，IF：4.939)

16.Xie SZ, Tai SH, Song HX, Luo XM, Zhang H, Li XH.Genetically engineering of Escherichia coli and immobilization on electrospun fibers for drug delivery purposes.JOURNAL OF MATERIALS CHEMISTRY B.2016,4: 6820-6829.(1区，IF：6.331)

17.Guo ZQ, Xia T, Wang H, Cheng F, Cheng R, Luo XM, Li XH.Electrosprayed Microparticles with Loaded pDNA-Calcium Phosphate Nanoparticles to Promote the Regeneration of Mature Blood Vessels.PHARMACEUTICAL RESEARCH.2014,31: 874-886.(1区，IF：4.2)

18.Xiaoming Luo^＃,Hong Zhang＃, Huan Wang, Chaoyu Liu, Yun zhang, Xiaohong Li*, Antimetastasis and antitumor efficacy promoted by sequential release of vascular disrupting and chemotherapeutic agents from electrospun fibers. International journal of pharmaceutics, 2014, 475: 438–449（5）( 2区，IF：4.845)

19.Xiaoming Luo^＃,Guisen Xu＃,Shuxia Yang, Shili Yan, Guoqing Jia, Xiaohong Li*, Promoted antitumor activities of acid-labile electrospun fibers loaded with hydroxycamptothecin via intratumoral implantation. European Journal of Pharmaceutics and Biopharmaceutics, 2012, 82: 545–553( 2区，IF：4.604)

20.Xiaoming Luo^＃,Chengying Xie＃, Huan Wang, Chaoyu Liu, Shili Yan, Xiaohong Li*, Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation. International journal of pharmaceutics. 2012, 425：19-28( 2区，IF：4.845)

21.Xie CY, Li XH, Luo XM, Yang Y,Cui WG,Zou J, Zhou SB.Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-beta-cyclodextrin inoculations.International journal of pharmaceutics.2010, 391:55-64.

22.王淑瑶，卢瑞，兰维杰，兰文婷，王毅豪，张 蓉，邱宝伟，秦思玥，刘耀文，罗晓明*.不同壳聚糖含量对壳聚糖/聚乙烯醇复合塑料薄膜性能影响的研究.《塑料工业》,2017;45:94-97.

23.张蓉，王淑瑶，王毅豪，兰文婷，袁亮，刘耀文，罗晓明*，聚乳酸– 壳聚糖 – 茶多酚复合膜的制备及其性能.《工程塑料应用》，2017；45：46-51.

24.陈朝琼,康镇,黄启航,孟荣,罗晓明*，李倩,胡廷武.川西北草原药花蜂蜜的品质研究.《食品安全质量检测学报》，2017；8：630-633.

四、会议报告

1.Xiaoming Luo^＃, Electrospinning nanofibers as local intratumoral implants for cancer chemotherapy,2016Employing Information and Communications Technologies in Homes and Cities for the Health and Well-Being of Older People, Chengdu, P.R. China , 15 - 17 August 2016.